Stephenson Cancer Center Research Points to More Effective Diagnostic Test for Leukemia PatientsMonday, June 11, 2018 -
New research, led by Stephenson Cancer Center physician-scientist
Jennifer Holter-Chakrabarty, MD, points to a potentially more effective
diagnostic test for marrow recovery in patients leukemia undergoing bone
marrow and stem cell transplants. This research was recently published
in the journal, Lancet Haematology.
The 18F-FLT is highly visible in PET and CT scans, providing a more comprehensive image of the bone marrow compartment and can better differentiate between bone marrow growth or non-growth in some patients as soon as five days following a marrow transplantation.
“With this novel imaging, it’s the first time that someone can
predict bone marrow cell growth early following an infusion,” said
Holter. “We can tell more quickly if a transplant is working and if
there is an early growth pattern among new blood cells and the immune
“This testing increases the ability to see what is going on in the
marrow, helping us guide our decisions. It is also an example of why
clinical trials are important. The patients involved in this study not
only may help themselves, but they are also helping improve the lives of
others who may battle the disease in the future."
This study received funding from the National Institutes of Health, Ben's Run/Ben's Gift, Albert and Elizabeth Tucker Foundation, Mex Frates Leukemia Fund, Jones Family fund, and Oklahoma Center for Adult Stem Cell Research.
The study, “Imaging of subclinical haemopoiesis after stem-cell transplantation in patients with haematological malignancies: a prospective pilot study,” was published in volume 5, issue 1 of Lancet Haematology. This exclusively online journal publishes high-impact research in advance treatments in haematological clinical practice. Holter served as a co-lead author on this study. Other Stephenson Cancer Center and OU Medicine investigators who participated in this study were: Quyen Duong, MS; Sara K. Vesely, PhD; Chuong T. Nguyen, PhD; Joseph P. Havlicek, PhD; George Selby, MD; Shibo Li, MD; and Teresa Scordino, MD.This study received funding from the National Institutes of Health, Ben's Run/Ben's Gift, Albert and Elizabeth Tucker Foundation, Mex Frates Leukemia Fund, Jones Family fund, and Oklahoma Center for Adult Stem Cell Research.
|University of Oklahoma HSC